Context is always helpful. Here's an example in context.
Byli jste v létě v hotelu? (nebo jiném ubytovacím zařízení?) Co vás v roli ubytovaných, tedy zákazníků, dokáže „zvednout ze židle“ nebo je pro vás nepříjemné, nepřijatelné? (linkedin)
Did you stay in a hotel or other accommodation in summer? As a guest or customer,
- what really gets up your nose?
- what really rubs you up the wrong way?
- what really sets your teeth on edge?
- what do you find really annoying/irritating?
- what really gets your back up?